A highly informative probe for two polymorphic Vh gene regions that contain one or more autoantibody-associated Vh genes.

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A highly informative probe for two polymorphic Vh gene regions that contain one or more autoantibody-associated Vh genes.

Efforts to determine the role of specific Ig variable region (V) genes in human autoimmune responses have been hampered by the lack of suitably polymorphic probes. Recently we isolated a heavy chain V (Vh) gene, designated Humhv3005, that is 99% homologous to the 1.9III Vh gene and can encode an anti-DNA antibody. To study the relation between these two genes, different DNA fragments from the i...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1989

ISSN: 0021-9738

DOI: 10.1172/jci114218